Vagifem is a local vaginal hormone replacement therapy medication used to treat menopausal changes in and around the vagina. It comes in a tablet containing Estradiol, which restores the levels of estrogen in the vagina.

During and after menopause, many women experience vaginal atrophy, which is when vaginal tissues get thinner and irritated more easily. Vaginal atrophy can lead to dryness, itchiness, and discomfort, which can then lead to painful intercourse. The root cause of vaginal atrophy is a decline in estrogen levels.

While over-the-counter (OTC) gels, ointments, and inserts may temporarily relieve dryness and discomfort, Vagifem can alleviate the dryness that causes these symptoms